Diagnostic and Prognostic Roles of GATA3 Immunohistochemistry in Urothelial Carcinoma

This study aimed to evaluate the diagnostic and prognostic roles of GATA-binding protein 3 (GATA3) immunohistochemistry in urothelial carcinoma (UC) using a meta-analysis. We investigated GATA3 immunohistochemical expression rates performed subgroup analysis based on tumor site, location, histological subtypes. The overall survival patients with GATA3-positive -negative UC were compared. estimated rate was 0.748 (95% confidence interval [CI]: 0.704–0.787). urinary bladder tract 0.775 CI: 0.727–0.818) 0.614 0.426–0.774), respectively. noninvasive invasive UCs 0.965 0.938–0.980) 0.644 0.581–0.702), In UCs, there significant difference between non-muscular invasion muscular subgroups (0.937, 95% 0.883–0.967 vs. 0.753, 0.645–0.836). highest microcytic subtype among histologic subtypes (0.952, 0.724–0.993). There correlation better prognosis (hazard ratio: 0.402, 0.311–0.521). Taken together, significantly correlated low-stage UC. is highly variable across subtypes, one should be careful while interpreting expression.